HYDRA-SCALP THERAPY

Hair Wash

ASTUTE PROGRAMME

HYDRA-SCALP THERAPY
PROGRAMME

What is a Hydra-Scalp?

HydraFacial Keravive cleanses, exfoliates, and hydrates the scalp and hair follicles. The treatment removes dirt, oil, flakes, dead skin cells and impurities from the surface of the scalp and from hair follicles and stimulates scalp circulation.

What we use for
Hydra-Scalp Therapy?

CALECIM ®
Professional

Advanced Hair System

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The Dermal Papilla Cell
Dermal

Dermal Papilla Cells (DPs)
are mesenchymal cells at the base of the hair follicle in the dermal papilla.
These cells play crucial roles in hair growth, formation and cycling, predominantly by secreting growth factors and molecules responsible for constructing the extracellular matrix.

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Understanding the Dermal Papilla Cell in Hair Follicle Cycling Private

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Causes
of Hair Loss

  • Inherited genetic susceptibility

  • Hormonal clutters

  • Immune system

  • Poor nutrition

  • Internal and external environmental elements

  • Mental disorders

  • Aging

All Factors impact the the hair cycle and hair follicle
recovery via

  • Cell Death

  • Inflammation around the tissue of the follicular

  • Release of damaging free radicals.

ANDROGENIC ALOPECIA (AGA) (HAIR LOSS)

  • A common medical problem affecting both males and females

  • Has negative psychological impact on affected individuals

  • Many potential causative factors

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INFLAMMATION
AND HAIR
LOSS

Many studies have shown perifollicular micro inflammation in PHL and FPHL. The micro inflammatory component is localized in the area of the bulge stem cell niche. This can eventually lead to a dysregulation of the hair follicle cycle and stem cell renewal.

How do Hair
Follicles get Inflamed

  • Environmental factors

  • ​Keratinocytes response to irritants

  • Free radicals cause damage, which triggers the release of inflammatory mediators, leading to upregulation of ROS.

  • Oxidative stress (caused by an imbalance of ROS in cells) decreases the antioxidant defence, leading to apoptosis.

  • Aging

Advanced Hair System Treatment

Promoting Hair Induction Ability with Stem Cell Growth Factors

Mesenchymal stem cell derived
signalling and growth factors are able to influence hair growth through

  • Cellular proliferation to prolong the ANAGEN phase

  • Inducing cell growth

  • Stimulating hair follicle development

  • Suppressing apoptotic cues

Key Growth Factors and
their Functions

Hepatocyte Growth Factor (HGF).
Works with HGF activator (discharged by DPs)
to enhance the proliferation of follicular epithelial cells.

Basic Fibroblast Growth Factors (b FGF)
improves the advancement of hair follicles.

Vascular Endothelial Growth Factor (VEGF)
allows for a significant increase in perifollicular vascularization
during the anagen phase of the hair cycle, followed by regression of angiogenic blood vessels during the catagen and telogen phase

Transforming Growth Factor β (TGF β)
stimulates the signalling pathways that manage the hair cycle

IGF 1 improves the migration, survival, and proliferation of HF cells
Furthermore, IGF 1 has been suggested to play a crucial role in regulating cellular differentiation
and tissue generation during the development of hair follicle.

Platelet derived Growth Factor (PDGF) binds to PDGF receptor β/ α, with an effect to up regulate the
genes associated with HF separation, induction, and control of anagen. PDGF and its receptors are hence
fundamental for follicular improvement.

In Vitro Trials of Cord Lining Conditioned Media on Human Follicle DP Cells

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Human follicle DP cells when exposed to CLCM showed
a 24 increase in Cellular Proliferation compared to the
Negative Control This was statistically similar to the DP
Cell Proliferation when exposed to Minoxidil at a
2 µg/ml concentration

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